Startup launches propolis-based skin care ingredient that could: “address unmet needs" in the beauty industry

By Kirsty Doolan

- Last updated on GMT

The ingredient has been shown to give impressive anti-wrinkle results and could "potentially reduce the reliance on common preservatives in skin care formulations" (Image: Getty)
The ingredient has been shown to give impressive anti-wrinkle results and could "potentially reduce the reliance on common preservatives in skin care formulations" (Image: Getty)
Croatia-based biotechnology R&D company ApiotiX Technologies said there is potential for its new ingredient to "transform the cosmetics industry” and "potentially reduce the reliance on common preservatives in skin care formulations."

It has utilised patented​ technology to develop a Phenolic Acids Polymer Extract that’s derived from propolis – a natural, bee-based product that is known for its anti-inflammatory, antioxidative, and antimicrobial properties – and said it could also potentially reduce the reliance on common preservatives in skin care formulations.

The startup, which is a spin-off from nutritional supplement business Hedera Ltd, said the new pharmaceutical-grade, standardised, natural extract formulation has “potent biological properties specially designed for skin care” ​and that this extract represents a “game-changer for the cosmetics industry.”

According to ApiotiX Technologies, the extract offers a natural solution for skin care, anti-ageing products, and inflammatory treatment. It also stated that it “demonstrates exceptional biological activity, influencing skin cells, and signalling pathways” ​and that it also “enhances the stability of typically delicate compounds, potentially reducing the reliance on common preservatives.”

"Proven clinical efficacy"

The COO of ApiotiX Technologies, Dr Božo Radić shared: "We firmly believe that our solution can address unmet needs in the luxury and prestige cosmetic industry. Our technology's solid scientific foundation and proven clinical efficacy make it a promising addition to the world of skin care."

The company has already secured patents for this technology across key markets such as US, EU, Japan, China, New Zealand, Mexico, and Brazil.

It also said it had “conducted a rigorous clinical study to validate the remarkable efficacy of its Phenolic Acids Polymer Extract in two concentrations: ‘A’ and ‘B’ creams applied twice a day.”

The double-blind study, which was conducted over 28 days with 40 female participants, including those with sensitive and non-sensitive dry skin, yielded “highly promising results in a dose-response manner,” ​according to Dr Radić.

Its key findings included:

  • After a 28-day regimen using product A (the lower extract dose), participants experienced an average improvement in anti-wrinkle efficacy by 25% compared to baseline.
  • In the case of product B (higher extract dose), a 34% average improvement in anti-wrinkle efficacy was observed after 28 days of continuous use.
  • A comprehensive dermatological assessment for tolerance was conducted over 56 days and revealed no adverse skin alterations associated with use of the cream.

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