The raw material for the ingredient is carob seeds and according to the France-based company it helps activate the skin’s natural repair systems that become less effective with age.
In older skin, the capacity of fibroblasts and keratinocytes to migrate to the site of damage, which is one of the key steps in tissue repair, is impaired.
Helps cells move to site of damage
Silab references in vitro studies that suggest Glyco- Repair can restore the migratory potential of the cells at a 1 percent concentration. According to Silab, this encourages the recolonisation of the damaged dermis and epidermis, which is a vital step in skin healing.
In addition, the company claims the ingredient normalises the synthesis of a family of growth factors that are important in skin repair.
The study results suggested that levels of activin A and TGF-beta1 are reduced in deficient keratinocytes (taken from older volunteers) and fibroblasts (obtained by consecutive replication of normal human fibroblasts).
According to Silab, Glyco-Repair increases activin A and TGF-beta1 in vitro, as well as stimulating alpha-SMA synthesis, a marker of myofibroblasts which plays an important role in skin repair.
The company has also performed a number of in vivo tests on damaged skin and says after 14 days of twice-daily applications the Glcyo-Repair cream performed better in comparison to a placebo, reducing the red colour of the skin and accelerating the recovery of the barrier function.
After 7 days of treatment the damaged lips of volunteers also benefited from the ingredient, added the company.
Silab will be presenting the ingredient to the Asian market at PCHI, and will tackle the European market at April’s InCosmetics show in Munich.